Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis
The in vivo studies conducted here with NQO treatment of human APOBEC3B expressing mice reveal a strong synergy at the pathological level through tumor formation and at the molecular level through mutational signature. This is a striking one-way synergy in which A3B SBS2 mutational events increase synergistically but NQO SBS4 events do not.
Read here: https://www.biorxiv.org/content/10.1101/2025.01.18.633716v1.full