Publications
SARS-CoV-2 3CLpro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376
Heilmann E, Costacurta F, Moghadasi SA, Ye C, Pavan M, Bassani D, Volland A, Ascher C, Weiss AKH, Bante D, Harris RS, Moro S, Rupp B, Martinez-Sobrido L, von Laer D.
Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides
Richards C.M., Li M., Perkins A.L., Rathore A., Harki D.A., & Harris RS.
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Moghadasi SA, Heilmann E, Khalil A, Nnabuife C, Kearns F, Ye C, Moraes SN, Costacurta F, Esler M, Aihara H, von Laer D, Martinez-Sobrido L, Palzkill T, Amaro RE, Harris R.
Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B
Argyris PP, Naumann J, Jarvis MC, Wilkinson PE, Ho DP, Islam MN, Bhattacharyya I, Gopalakrishnan R, Li F, Koutlas IG, Giubellino A, Harris RS.
Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species
Auerbach AA, Becker JT, Moraes SN, Moghadasi SA, Duda JM, Salamango DJ, Harris RS.
Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition
Shaban NM, Yan R, Shi K, Moraes SN, Cheng AZ, Carpenter MA, McLellan JS, Yu Z, Harris RS.
APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis
Sonja M Wörmann, Amy Zhang , Fredrik I Thege, Robert W Cowan, Dhwani N Rupani, Runsheng Wang, Sara L Manning, Chris Gates, Weisheng Wu, Rena Levin-Klein, Kimal I Rajapakshe, Meifang Yu, Asha S Multani, Ya’an Kang, Cullen M Taniguchi, Katharina Schlacher , Melena D Bellin, Matthew H G Katz, Michael P Kim, Jason B Fleming, Steven Gallinger, Ravikanth Maddipati, Reuben S Harris , Faiyaz Notta, Susan R Ross, Anirban Maitra, Andrew D Rhim
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers
Argyris PP, Wilkinson PE, Jarvis MC, Magliocca KR, Patel MR, Vogel RI, Gopalakrishnan R, Koutlas IG, Harris RS.
Structural Characterization of a Minimal Antibody against Human APOBEC3B
Tang H, Demir Ö, Kurniawan F, Brown WL, Shi K, Moeller NH, Carpenter MA, Belica C, Orellana K, Du G, LeBeau AM, Amaro RE, Harris RS, Aihara H.
Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q
Shi K, Moeller NH, Banerjee S, McCann JL, Carpenter MA, Yin L, Moorthy R, Orellana K, Harki DA, Harris RS, Aihara H.