Posts written by yorka

Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis

February 5, 2025

The in vivo studies conducted here with NQO treatment of human APOBEC3B expressing mice reveal a strong synergy at the pathological level through tumor formation and at the molecular level through mutational signature. This is a striking one-way synergy in which A3B SBS2 mutational events increase synergistically but NQO SBS4 events do not. Read here: […]