{"id":751,"date":"2025-02-05T15:42:45","date_gmt":"2025-02-05T15:42:45","guid":{"rendered":"https:\/\/labs.uthscsa.edu\/rsh\/?p=751"},"modified":"2025-02-05T15:44:27","modified_gmt":"2025-02-05T15:44:27","slug":"tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis","status":"publish","type":"post","link":"https:\/\/labs.uthscsa.edu\/rsh\/2025\/02\/05\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\/","title":{"rendered":"Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis"},"content":{"rendered":"<p>The in vivo studies conducted here with NQO treatment of human APOBEC3B expressing mice reveal a strong synergy at the pathological level through tumor formation and at the molecular level through mutational signature. This is a striking one-way synergy in which A3B SBS2 mutational events increase synergistically but NQO SBS4 events do not.<\/p>\n<p>Read here: https:\/\/www.biorxiv.org\/content\/10.1101\/2025.01.18.633716v1.full<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The in vivo studies conducted here with NQO treatment of human APOBEC3B expressing mice reveal a strong synergy at the pathological level through tumor formation and at the molecular level through mutational signature. This is a striking one-way synergy in which A3B SBS2 mutational events increase synergistically but NQO SBS4 events do not. Read here: [&hellip;]<\/p>\n","protected":false},"author":115,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"class_list":["post-751","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis - Harris Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/labs.uthscsa.edu\/rsh\/2025\/02\/05\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis - Harris Lab\" \/>\n<meta property=\"og:description\" content=\"The in vivo studies conducted here with NQO treatment of human APOBEC3B expressing mice reveal a strong synergy at the pathological level through tumor formation and at the molecular level through mutational signature. This is a striking one-way synergy in which A3B SBS2 mutational events increase synergistically but NQO SBS4 events do not. Read here: [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/labs.uthscsa.edu\/rsh\/2025\/02\/05\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\/\" \/>\n<meta property=\"og:site_name\" content=\"Harris Lab\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-05T15:42:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-05T15:44:27+00:00\" \/>\n<meta name=\"author\" content=\"yorka\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"yorka\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/rsh\\\/2025\\\/02\\\/05\\\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/rsh\\\/2025\\\/02\\\/05\\\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\\\/\"},\"author\":{\"name\":\"yorka\",\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/rsh\\\/#\\\/schema\\\/person\\\/801e04c20d9cc01e94a7b7351c40b229\"},\"headline\":\"Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis\",\"datePublished\":\"2025-02-05T15:42:45+00:00\",\"dateModified\":\"2025-02-05T15:44:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/rsh\\\/2025\\\/02\\\/05\\\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\\\/\"},\"wordCount\":74,\"commentCount\":0,\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/labs.uthscsa.edu\\\/rsh\\\/2025\\\/02\\\/05\\\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/rsh\\\/2025\\\/02\\\/05\\\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\\\/\",\"url\":\"https:\\\/\\\/labs.uthscsa.edu\\\/rsh\\\/2025\\\/02\\\/05\\\/tobacco-smoke-carcinogens-exacerbate-apobec-mutagenesis-and-carcinogenesis\\\/\",\"name\":\"Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis - 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