APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

Leonard B., Starrett G.J., Maurer M.J., Oberg A.L., Van Bockstal M., Van Dorpe J., De Wever O., Helleman J., Sieuwerts A.M., Berns E.M., Martens J.W., Anderson B.D., Brown W.L., Kalli K.R., Kaufmann S.H., Harris R.S


Purpose: APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated APOBEC3 activity causes mutations in cancer. Because of broad expression profiles and varying mixtures of normal and cancer cells in tumors, including immune cell infiltration, it is difficult to determine where different APOBEC3s are expressed. Here, we ask whether correlations exist between APOBEC3 expression and T-cell infiltration in high-grade serous ovarian cancer (HGSOC), and assess whether these correlations have prognostic value.