{"id":11,"date":"2024-07-11T18:19:33","date_gmt":"2024-07-11T18:19:33","guid":{"rendered":"https:\/\/labs.uthscsa.edu\/rasmussen\/?page_id=11"},"modified":"2026-01-15T16:53:36","modified_gmt":"2026-01-15T16:53:36","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.uthscsa.edu\/rasmussen\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

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Current Projects<\/h2>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”277″ img_size=”large” css=””][\/vc_column][vc_column width=”5\/12″]

Muscle Disuse Study<\/h3><\/a>[vc_column_text css=””]This study looks at the loss of muscle in middle aged individuals after being on crutches for an extended period of time. After this, participants are put on an exercise regime. This study aims to build a deeper understanding on muscle loss and regrowth in individuals after injuries.[\/vc_column_text][\/vc_column][vc_column width=”1\/3″] \n \n \n <\/i>\n <\/i>\n <\/span>

Publications<\/h3>\n <\/a>[\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”31″ img_size=”large” css=””][\/vc_column][vc_column width=”3\/4″]

DEPDC5 Muscle-Specific Knockout Study<\/h3><\/a>[vc_column_text css=””]Overnutrition is known to cause insulin resistance and inflammation, exacerbated by increased age, but the mechanisms involved are not well understood. This work aims to understand the connection between inflammation and cellular senescence to insulin resistance using diet induced obesity and diabetes in both aged mice and mice with hyperactive mTORC1 signaling in skeletal muscle.<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”281″ img_size=”large” css=””][\/vc_column][vc_column width=”3\/4″]

Mechanisms of magnesium handling in exercising skeletal muscle<\/h3><\/a>[vc_column_text css=””]Magnesium is extremely important for exercising skeletal muscle because of its requirement for the production and breakdown of ATP- the energy currency of the cell. We are investigating the effects of impaired magnesium uptake into the sarcoplasmic reticulum by knocking out the ERMA protein, a known magnesium transporter. We hypothesize that mice lacking ERMA in skeletal muscle will have impaired magnesium uptake, dysregulated calcium handling, and greater susceptibility to fatigue during exercise.<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”31″ img_size=”large” css=””][\/vc_column][vc_column width=”3\/4″]

HDC Muscle-Specific Histidine Decarboxylase Knockout Study<\/h3><\/a>[vc_column_text css=””][\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” el_class=”margin-bottom-2″][vc_column width=”2\/3″][vc_column_text css=””]<\/p>\n

Past Projects<\/h2>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”139″ img_size=”full” css=””][\/vc_column][vc_column width=”3\/4″]

MoTrPAC<\/h3><\/a>[vc_column_text css=””]The Molecular Transducers of Physical Activity Consortium (MoTrPAC) aims to uncover, at the molecular level, how exercise improves and maintains the health of the body\u2019s tissues and organs.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”276″ img_size=”large” css=””][\/vc_column][vc_column width=”3\/4″]

Exercise Training in Older Adults<\/h3><\/a>[vc_column_text css=””]This study examined how 12 weeks of progressive resistance training alters skeletal muscle gene expression in young (~20s) and older (~70s) men. Training produced substantial but largely distinct transcriptomic changes in each age group, with older muscle showing a larger overall response. Notably, resistance exercise reduced ATF4-activated and senescence-associated mRNAs in older men, and gains in lean mass and strength were linked to increased expression of genes involved in mitochondrial function, translation, rRNA processing, and polyamine metabolism.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row full_width=”stretch_row”][vc_column width=”2\/3″][vc_column_text css=””] Current Projects [\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”277″ img_size=”large” css=””][\/vc_column][vc_column width=”5\/12″][vc_column_text css=””]This study looks at the loss of muscle in middle aged individuals after being on crutches for an extended period of time. After this, participants are put on an exercise regime. This study aims to build a deeper understanding on muscle […]<\/p>\n","protected":false},"author":94,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"yoast_head":"\nResearch - Rasmussen Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/labs.uthscsa.edu\/rasmussen\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Rasmussen Lab\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=”stretch_row”][vc_column width=”2\/3″][vc_column_text css=””] Current Projects [\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle”][vc_column width=”1\/4″][vc_single_image image=”277″ img_size=”large” css=””][\/vc_column][vc_column width=”5\/12″][vc_column_text css=””]This study looks at the loss of muscle in middle aged individuals after being on crutches for an extended period of time. After this, participants are put on an exercise regime. 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