https:\/\/www.jci.org\/articles\/view\/184069<\/a><\/p>\nAbout the Huang Lab<\/strong><\/p>\nThe Huang Lab at UT Health San Antonio is a basic and translational cancer research group within the MD Anderson Mays Cancer Center at UT Health San Antonio. The team integrates hematology and solid\u2011tumor biology with immunology and metabolism to uncover mechanisms and design interventions. The lab advances cell and biologic therapies, including CAR T\u2011cell approaches for solid tumors, and also pursues research in trauma and military health. Through collaboration, product\u2011minded innovation, and hands\u2011on training, the Huang Lab works to move discoveries into solutions that improve patient outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"
SAN ANTONIO, Texas \u2014 The Huang Lab at the Mays Cancer Center at UT Health San Antonio announces a new publication in the Journal of Clinical Investigation that defines an essential role for CPT1A in hematopoietic stem cell (HSC) maintenance. The study, published January 9, 2025, reports that deleting Cpt1a in the hematopoietic system disrupts […]<\/p>\n","protected":false},"author":101,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"class_list":["post-529","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"\n
Huang Lab Publishes JCI Study Linking Cpt1a Loss to Metabolic Rewiring and Defective Hematopoietic Stem Cells - Gang Huang Lab<\/title>\n<meta name=\"description\" content=\"Huang Lab publishes in the Journal of Clinical Investigation: Cpt1a loss rewires HSC metabolism toward glucose\u2011fueled OXPHOS, disrupting quiescence and self\u2011renewal.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/labs.uthscsa.edu\/huang\/2025\/01\/09\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Huang Lab Publishes JCI Study Linking Cpt1a Loss to Metabolic Rewiring and Defective Hematopoietic Stem Cells - Gang Huang Lab\" \/>\n<meta property=\"og:description\" content=\"Huang Lab publishes in the Journal of Clinical Investigation: Cpt1a loss rewires HSC metabolism toward glucose\u2011fueled OXPHOS, disrupting quiescence and self\u2011renewal.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/labs.uthscsa.edu\/huang\/2025\/01\/09\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Gang Huang Lab\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-09T19:17:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-30T19:21:22+00:00\" \/>\n<meta name=\"author\" content=\"phamv1\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"phamv1\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/huang\\\/2025\\\/01\\\/09\\\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/huang\\\/2025\\\/01\\\/09\\\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\\\/\"},\"author\":{\"name\":\"phamv1\",\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/huang\\\/#\\\/schema\\\/person\\\/cf446891ab1c3b1a0d2f8f570fe622ad\"},\"headline\":\"Huang Lab Publishes JCI Study Linking Cpt1a Loss to Metabolic Rewiring and Defective Hematopoietic Stem Cells\",\"datePublished\":\"2025-01-09T19:17:39+00:00\",\"dateModified\":\"2025-07-30T19:21:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/huang\\\/2025\\\/01\\\/09\\\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\\\/\"},\"wordCount\":322,\"commentCount\":0,\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/labs.uthscsa.edu\\\/huang\\\/2025\\\/01\\\/09\\\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/labs.uthscsa.edu\\\/huang\\\/2025\\\/01\\\/09\\\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\\\/\",\"url\":\"https:\\\/\\\/labs.uthscsa.edu\\\/huang\\\/2025\\\/01\\\/09\\\/huang-lab-publishes-jci-study-linking-cpt1a-loss-to-metabolic-rewiring-and-defective-hematopoietic-stem-cells\\\/\",\"name\":\"Huang Lab Publishes JCI Study Linking Cpt1a Loss to Metabolic Rewiring and Defective Hematopoietic Stem Cells - 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