{"id":526,"date":"2024-08-04T10:00:25","date_gmt":"2024-08-04T10:00:25","guid":{"rendered":"https:\/\/labs.uthscsa.edu\/huang\/?p=526"},"modified":"2025-07-30T19:50:17","modified_gmt":"2025-07-30T19:50:17","slug":"huang-lab-spins-off-ph102-and-solid%e2%80%91tumor-cell-therapy-programs-into-powerhouse-therapeutics","status":"publish","type":"post","link":"https:\/\/labs.uthscsa.edu\/huang\/2024\/08\/04\/huang-lab-spins-off-ph102-and-solid%e2%80%91tumor-cell-therapy-programs-into-powerhouse-therapeutics\/","title":{"rendered":"Huang Lab Spins Off PH102 and Solid\u2011Tumor Cell Therapy Programs into Powerhouse Therapeutics Inc"},"content":{"rendered":"<p>SAN ANTONIO, Texas \u2014 The Huang Lab at the Mays Cancer Center at UT Health San Antonio announced the formation of Powerhouse Therapeutics Inc, a biotechnology startup created to advance PH102 and a subset of the lab\u2019s solid\u2011tumor cell therapy portfolio toward the clinic. The new company will focus on translational development, manufacturing readiness, and regulatory milestones while the Huang Lab continues discovery research and early preclinical studies.<\/p>\n<p>PH102 is a GPC3\u2011targeted CAR T\u2011cell therapy in development for hepatocellular carcinoma. Preclinical data support its potential to address resistance in solid tumors. By moving PH102 and related programs into an industry vehicle, the team aims to shorten the path from proof\u2011of\u2011concept to first\u2011in\u2011human evaluation.<\/p>\n<p>\u201cThe spin\u2011off lets us keep doing what we do best in the academic setting while ensuring our most promising assets have the dedicated resources needed for clinical translation,\u201d said Dr. Gang Huang, principal investigator of the Huang Lab. \u201cIt strengthens our collaborations with clinicians and industry and keeps patients at the center of our goals.\u201d<\/p>\n<p>\u201cPowerhouse Therapeutics will concentrate on IND\u2011enabling studies, process development, and partnerships that position these therapies for real\u2011world impact,\u201d said Vincent Pham, CEO of Powerhouse Therapeutics. \u201cWe look forward to building on the lab\u2019s science with a focused development plan.\u201d<\/p>\n<p>Powerhouse Therapeutics was founded by scientists affiliated with UT Health San Antonio. The company will collaborate with academic and clinical partners to advance cell therapies for treatment\u2011resistant solid tumors. The Huang Lab remains committed to rigorous discovery, training, and open scientific collaboration. To learn more, visit the company&#8217;s website at: <a href=\"https:\/\/www.ph-therapeutics.com\/\">https:\/\/www.ph-therapeutics.com\/<\/a><\/p>\n<p><strong>About the Huang Lab<\/strong><\/p>\n<p>The Huang Lab at UT Health San Antonio is a basic and translational cancer research group within the MD Anderson Mays Cancer Center at UT Health San Antonio. Our team integrates hematology and solid tumor biology with immunology and metabolism to uncover mechanisms and design interventions. We advance cell and biologic therapies, including CAR T\u2011cell approaches for solid tumors. We also conduct research in trauma and military health. We move discoveries toward clinical impact through product development and collaborations with clinicians and industry. Education and mentorship are core to our mission. We train students, postdoctoral fellows, and early\u2011career scientists in rigorous, multidisciplinary research. Together, we aim to deliver therapies and technologies that improve patient outcomes.<\/p>\n<p><strong>About Powerhouse Therapeutics<\/strong><\/p>\n<p>Powerhouse Therapeutics Inc is a biotechnology company developing cell-based therapies that tackle treatment resistance in solid tumors and fibrotic diseases. Built on our proprietary Immune Triad Therapy with Armed CAR T-cell Supercharger (IT-ACTS) platform, we engineer multimodal living drugs that deliver targeted payloads, remodel the tumor microenvironment, and restore tissue homeostasis. Our lead candidate, PH102, is an autologous IT-ACTS therapy poised for clinical entry, with off-the-shelf and anti-fibrotic programs advancing in parallel. Founded by leading academic scientists, we combine academic rigor with translational speed to deliver paradigm-shifting therapies for all patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SAN ANTONIO, Texas \u2014 The Huang Lab at the Mays Cancer Center at UT Health San Antonio announced the formation of Powerhouse Therapeutics Inc, a biotechnology startup created to advance PH102 and a subset of the lab\u2019s solid\u2011tumor cell therapy portfolio toward the clinic. The new company will focus on translational development, manufacturing readiness, and [&hellip;]<\/p>\n","protected":false},"author":101,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"class_list":["post-526","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Huang Lab Spins Off PH102 and Solid\u2011Tumor Cell Therapy Programs into Powerhouse Therapeutics Inc - Gang Huang Lab<\/title>\n<meta name=\"description\" content=\"Huang Lab announces the spin\u2011off of PH102 and select solid\u2011tumor cell therapy programs into Powerhouse Therapeutics to accelerate translation and clinical development.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/labs.uthscsa.edu\/huang\/2024\/08\/04\/huang-lab-spins-off-ph102-and-solid\u2011tumor-cell-therapy-programs-into-powerhouse-therapeutics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Huang Lab Spins Off PH102 and Solid\u2011Tumor Cell Therapy Programs into Powerhouse Therapeutics Inc - 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