Huang Lab Awarded Morrison Trust Grant to Study Tumor‑Derived Lactate in Cancer‑Associated Cachexia
SAN ANTONIO, Texas — The Huang Lab at the Mays Cancer Center at UT Health San Antonio has been selected for funding by the Morrison Trust for the project “Mechanisms of tumor‑derived lactate in blood as a driver of cancer‑associated cachexia.”
Cancer‑associated cachexia is a metabolic syndrome that worsens outcomes and quality of life. This project will examine how lactate released by tumors circulates in blood, reprograms distant tissues, and contributes to muscle and fat loss. The team will apply rigorous mechanistic and translational approaches to identify actionable targets.
“We are grateful to the Morrison Trust for this investment,” said Gang Huang, PhD, principal investigator. “Understanding how tumor‑derived lactate drives systemic wasting can open new therapeutic paths for patients.”
“This support accelerates our work toward measurable clinical impact,” said Vincent Pham, Cancer Biology PhD Candidate. “We aim to define clear mechanisms that point to interventions.”
The Morrison Trust supports research and the improvement of methods to treat and prevent human illness. Its mission spans nutrition, blood chemistry, radionics, electricity, and related fields. The Trust also advances the sharing and application of new knowledge by qualified clinicians and institutions.
About the Huang Lab
The Huang Lab at UT Health San Antonio is a basic and translational cancer research group within the MD Anderson Mays Cancer Center at UT Health San Antonio. The team integrates hematology and solid‑tumor biology with immunology and metabolism to uncover mechanisms and design interventions. The lab advances cell and biologic therapies, including CAR T‑cell approaches for solid tumors, and also pursues research in trauma and military health. Through collaboration, product‑minded innovation, and hands‑on training, the Huang Lab works to move discoveries into solutions that improve patient outcomes.