{"id":344,"date":"2019-01-31T22:54:57","date_gmt":"2019-01-31T22:54:57","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/product-research-lab\/?page_id=344"},"modified":"2026-04-02T14:41:15","modified_gmt":"2026-04-02T14:41:15","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.uthscsa.edu\/burma\/","title":{"rendered":"Burma Lab"},"content":{"rendered":"

[vc_row][vc_column width=”2\/3″][vc_column_text]<\/p>\n

About this Research Lab<\/h2>\n

Research in the Burma Laboratory is focused on the responses of mammalian cells to DNA double-strand breaks (DSBs), collectively called the DNA damage response (DDR).<\/h3>\n

We are involved in studying DDR events triggered by ionizing radiation and their carcinogenic and cancer therapeutic implications. We are particularly interested in:<\/h3>\n

1. Understanding DSB signaling and repair mechanisms, with a focus on the regulation of DNA end resection.<\/h3>\n

2. Genetic basis of radio- and chemo-resistance of glioblastomas (GBM), with the translational objective of targeting DNA repair pathways for GBM therapy.<\/h3>\n

3. Genetic changes underlying gliomagenesis triggered by ionizing radiation, the only known risk factor for the development of GBM.<\/h3>\n

4. Radiation-induced senescence as a driver of glioblastoma recurrence, with the clinical objective of blunting recurrence using senolytic approaches.<\/h3>\n

A more mechanistic understanding of DDR events has emerged from our studies, providing important insights into how GBM is triggered, and leading to the development of better therapeutic approaches for GBM.<\/h3>\n

 <\/p>\n

\u201cScience is built of facts the way a house is built of bricks; but an accumulation of facts is no more science than a pile of bricks is a house.\u201d – Henri Poincar\u00e9<\/strong><\/h3>\n

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Lab Address<\/h3>\n

South Texas Research Facility (STRF), Room 288
\nGreehey Campus, UT Health Science Center
\n8403 Floyd Curl Dr, San Antonio, TX 78229<\/a><\/p>\n

Lab phone: 210-450-8585<\/a><\/p>\n

\"\"[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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